All living cells utilize intricate DNA repair mechanisms to address numerous types of DNA
lesions and to preserve genomic integrity, and pluripotent stem cells have specific needs …

Many surveillance and repair mechanisms exist to maintain the integrity of our genome. All
of the pathways described to date are controlled exclusively by proteins, which through their …

Brain tumours kill more children and adults under 40 than any other cancer. Around half of
primary brain tumours are glioblastoma multiforme (GBMs) where treatment remains a …

Background Pediatric high-grade gliomas (pHGG) are the leading cause of cancer-related
death during childhood. Due to their diffuse growth characteristics, chemoresistance and …

Blood cells are challenged by intrinsic and exogenous stress that may result in many types
of damage to DNA. As a major participant in cell-mediated immunity in blood, T lymphocytes …

Squamous cell carcinoma of the head and neck (HNSCC) most frequently arise in the
epithelial tissues of the upper aerodigestive tract. Patients with HNSCC, aged< 45 years are …

Stem cells are endowed with the awesome power of self-renewal and multi-lineage
differentiation that allows them to be major contributors to tissue homeostasis. Owing to their …

Localized prostate cancer (confined to the gland) generally is considered curable, with
nearly a 100% 5-year-survival rate. When the tumor escapes the prostate capsule, leading …

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world, with the
second highest mortality rate among all cancer types. Growing evidence has demonstrated …

Localized prostate cancer (confined to the gland) generally is considered curable, with
nearly a 100% 5-year-survival rate. When the tumor escapes the prostate capsule, leading …