The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …

The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …

Fibroblast heterogeneity has long been recognized in mouse and human lungs,
homeostasis, and disease states. However, there is no common consensus on fibroblast …

Expansion and activation of fibroblasts following cardiac injury is important for repair but
may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the …

The human lung plays vital roles in respiration, host defense, and basic physiology. Recent
technological advancements such as single-cell RNA sequencing and genetic lineage …

Recent breakthroughs in 3-dimensional (3D) organoid cultures for many organ systems
have led to new physiologically complex in vitro models to study human development and …

Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …

Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by
large amounts of extracellular matrix, which may lead to organ dysfunction and even death …

The bone morphogenetic protein (BMP) signaling pathway, including antagonists, functions
in lung development and regeneration of tracheal epithelium from basal stem cells. Here, we …