[HTML][HTML] Properties and functions of fibroblasts and myofibroblasts in myocardial infarction
The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …
[HTML][HTML] The cellular and physiological basis for lung repair and regeneration: past, present, and future
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …
[HTML][HTML] Multipotent stromal cells: one name, multiple identities
Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …
regeneration of most tissues. They can differentiate along multiple connective lineages, but …
[HTML][HTML] Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis
Fibroblast heterogeneity has long been recognized in mouse and human lungs,
homeostasis, and disease states. However, there is no common consensus on fibroblast …
homeostasis, and disease states. However, there is no common consensus on fibroblast …
Fibroblasts in the infarcted, remodeling, and failing heart
C Humeres, NG Frangogiannis - JACC: Basic to Translational Science, 2019 - jacc.org
Expansion and activation of fibroblasts following cardiac injury is important for repair but
may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the …
may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the …
[HTML][HTML] A census of the lung: CellCards from LungMAP
The human lung plays vital roles in respiration, host defense, and basic physiology. Recent
technological advancements such as single-cell RNA sequencing and genetic lineage …
technological advancements such as single-cell RNA sequencing and genetic lineage …
[HTML][HTML] In vitro generation of human pluripotent stem cell derived lung organoids
BR Dye, DR Hill, MAH Ferguson, YH Tsai, MS Nagy… - elife, 2015 - elifesciences.org
Recent breakthroughs in 3-dimensional (3D) organoid cultures for many organ systems
have led to new physiologically complex in vitro models to study human development and …
have led to new physiologically complex in vitro models to study human development and …
[HTML][HTML] Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function
BLM Hogan, CE Barkauskas, HA Chapman, JA Epstein… - Cell stem cell, 2014 - cell.com
Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …
[HTML][HTML] The bright side of fibroblasts: molecular signature and regenerative cues in major organs
RN Gomes, F Manuel, DS Nascimento - NPJ Regenerative Medicine, 2021 - nature.com
Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by
large amounts of extracellular matrix, which may lead to organ dysfunction and even death …
large amounts of extracellular matrix, which may lead to organ dysfunction and even death …
Niche-mediated BMP/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation
MI Chung, M Bujnis, CE Barkauskas… - …, 2018 - journals.biologists.com
The bone morphogenetic protein (BMP) signaling pathway, including antagonists, functions
in lung development and regeneration of tracheal epithelium from basal stem cells. Here, we …
in lung development and regeneration of tracheal epithelium from basal stem cells. Here, we …