Synthetic lethal interactions, where mutation of one gene renders cells sensitive to inhibition
of another gene, can be exploited for the development of targeted therapeutics in cancer …

Tumor cells can result from gene mutations and over-expression. Synthetic lethality (SL)
offers a desirable setting where cancer cells bearing one mutated gene of an SL gene pair …

Oncogenic alterations in human epidermal growth factor receptor 2 (HER2) occur in
approximately 2% of patients with non-small cell lung cancer and predominantly affect the …

Expression of the non-coding RNA XIST is essential for initiating X chromosome inactivation
(XCI) during early development in female mammals. As the main function of XCI is to enable …

Certain cancer types afflict female and male patients disproportionately. The reasons
include differences in male/female physiology, effect of sex hormones, risk behavior …

Ribosomal heterogeneity exists within cells and between different cell types, at specific
developmental stages, and occurs in response to environmental stimuli. Mounting evidence …

More than half of the~ 20,000 protein-encoding human genes have paralogs. Chemical
proteomics has uncovered many electrophile-sensitive cysteines that are exclusive to …

DDX3X is an RNA helicase with many functions in RNA metabolism such as mRNA
translation, alternative pre-mRNA splicing and mRNA stability, but also plays a role as a …

Recent advances in DNA sequencing technology have enabled the precise decoding of
genomes in non-model organisms, providing a basis for unraveling the patterns and …

Simple Summary A variety of anticancer therapeutic targets have been identified over the
decades. Nevertheless, the complexity of biological regulation dictates the necessity of …