Advancing pharmacogenomics from single-gene to preemptive testing

CE Haidar, KR Crews, JM Hoffman… - Annual review of …, 2022 - annualreviews.org
Pharmacogenomic testing can be an effective tool to enhance medication safety and
efficacy. Pharmacogenomically actionable medications are widely used, and approximately …

Implementation of pharmacogenomics: Where are we now?

S Medwid, RB Kim - British Journal of Clinical Pharmacology, 2024 - Wiley Online Library
Pharmacogenomics (PGx), examining the effect of genetic variation on interpatient variation
in drug disposition and response, has been widely studied for several decades. However, as …

Introducing HL7 FHIR Genomics Operations: a developer-friendly approach to genomics-EHR integration

RH Dolin, BSE Heale, G Alterovitz… - Journal of the …, 2023 - academic.oup.com
Objective Enabling clinicians to formulate individualized clinical management strategies
from the sea of molecular data remains a fundamentally important but daunting task. Here …

Clinician adherence to pharmacogenomics prescribing recommendations in clinical decision support alerts

JQ Nguyen, KR Crews, BT Moore… - Journal of the …, 2023 - academic.oup.com
Thoughtful integration of interruptive clinical decision support (CDS) alerts within the
electronic health record is essential to guide clinicians on the application of …

Pharmacogenomic clinical decision support: a scoping review

DM Smith, DT Wake… - Clinical Pharmacology & …, 2023 - Wiley Online Library
Clinical decision support (CDS) is often cited as an essential part of pharmacogenomics
(PGx) implementations. A multitude of strategies are available; however, it is unclear which …

The critical role of pharmacists in the clinical delivery of pharmacogenetics in the US

SB Haga - Pharmacy, 2023 - mdpi.com
Since the rebirth of pharmacogenomics (PGx) in the 1990s and 2000s, with new discoveries
of genetic variation underlying adverse drug response and new analytical technologies such …

Explainable artificial intelligence (XAI) in medical decision support systems (MDSS): applicability, prospects, legal implications, and challenges

The healthcare sector is very interested in machine learning (ML) and artificial intelligence
(AI). Nevertheless, applying AI applications in scientific contexts is difficult because of the …

Impact of transitioning to an active, noninterruptive CYP2C19/proton pump inhibitor alert on prescribing patterns

A Massmann, NJ Petry - American Journal of Health-System …, 2023 - academic.oup.com
Purpose To compare rates of prescriber acceptance of interruptive and noninterruptive
clinical decision support (CDS) alerts regarding potential diminished therapeutic …

Clinical decision support for precision dosing: opportunities for enhanced equity and inclusion in health care

JH Hughes, KH Woo, RJ Keizer… - Clinical Pharmacology …, 2023 - Wiley Online Library
Precision dosing aims to tailor doses to individual patients with the goal of improving
treatment efficacy and avoiding toxicity. Clinical decision support software (CDSS) plays a …

Understanding general practitioner and pharmacist preferences for pharmacogenetic testing in primary care: a discrete choice experiment

JH McDermott, V Sharma, GM Beaman… - The …, 2024 - nature.com
Pharmacogenetic testing in the United Kingdom's National Health Service (NHS) has
historically been reactive in nature, undertaken in the context of single gene-drug …