Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …

Virtually all cell types have the same DNA, yet each type exhibits its own cell-specific pattern
of gene expression. During the brief period of mitosis, the chromosomes exhibit changes in …

Cell migration occurs in confined microenvironments, which plays a vital role in the process
of tumor metastasis. However, it is challenging to study their behaviors in vivo. Here we …

Single cell proteomics is a powerful tool with potential for markedly enhancing
understanding of cellular processes. Here we report the development and application of …

Alterations in nuclear structure and function are hallmarks of cancer cells. Little is known
about these changes in Cancer-Associated Fibroblasts (CAFs), crucial components of the …

A-type lamins are the main structural components of the nucleus, which are mainly localized
at the nucleus periphery. First of all, A-type lamins, together with B-type lamins and proteins …

The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects,
regulates, and organizes the eukaryote genome and adapts to epigenetic changes and to its …

Lamins are the ancient type V intermediate filament proteins contributing to diverse
biological functions, such as the maintenance of nuclear morphology, stabilization of …

Abstract Hutchinson–Gilford Progeria Syndrome (HGPS) is an extremely rare genetic
disorder caused by mutations in the LMNA gene and characterized by premature and …

The repair of large bone defects due to trauma, disease, and infection can be exceptionally
challenging in the elderly. Despite best clinical practice, bone regeneration within …