Intrinsically disordered regions (IDRs) are especially enriched among proteins that regulate
chromatin and transcription. As a result, mechanisms that influence specificity of IDR-driven …

Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules
that perform key regulatory functions and drive dynamic complex formation. For decades …

Almost twenty years after its initial release, the Eukaryotic Linear Motif (ELM) resource
remains an invaluable source of information for the study of motif-mediated protein-protein …

Studies on the DNA-binding properties of transcription factors are important in searching for
the downstream genes regulated by these factors. In the present study, we report on the …

Specific protein–protein interactions are central to all processes that underlie cell
physiology. Numerous studies have together identified hundreds of thousands of human …

The modification of intracellular proteins with O-linked β-N-acetylglucosamine (O-GlcNAc)
moieties is a highly dynamic process that spatiotemporally regulates nearly every important …

Protein serine/threonine phosphatases (PPPs) are ancient enzymes, with distinct types
conserved across eukaryotic evolution. PPPs are segregated into types primarily on the …

Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host
factors. However, most current large-scale methods do not identify this important class of …

Protein phosphorylation is one of the most widely observed and important post-translational
modification (PTM) processes. Protein phosphorylation is regulated by protein kinases, each …

CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but
chemokine network redundancy thwarts pharmacological intervention. Tick evasins …