Glioblastoma (GB), the most aggressive malignant glioma, is made up of a large percentage
of glioma-associated microglia/macrophages (GAM), suggesting that immune cells play an …

Gap junctions are specialized cell-to-cell contacts that allow the direct transfer of small
molecules between cells. A single gap junction channel consists of two hemichannels, or …

Microglia are macrophage-like resident immune cells that contribute to the maintenance of
homeostasis in the central nervous system (CNS). Abnormal activation of microglia can …

Microglia represent the immune system of the brain. Their role is central in two phenomena,
neuroinflammation and oxidative stress, which are at the roots of different pathologies …

The frequent use of chemotherapy to combat a range of malignancies can elicit severe
cognitive dysfunction often referred to as “chemobrain,” a condition that can persist long after …

The adult subventricular zone (SVZ) of the mammalian brain contains neural progenitor cells
(NPCs) that continuously produce neuroblasts throughout life. These neuroblasts migrate …

The incidence of brain pathologies has increased during last decades. Better diagnosis
(autism spectrum disorders) and longer life expectancy (Parkinson's disease, Alzheimer's …

Under physiological conditions, microglia adopt a resting phenotype associated with the
production of anti-inflammatory and neurotrophic factors. In response to a wide variety of …

Gap junction (GJ) channels and their connexins (Cxs) are complex proteins that have
essential functions in cell communication processes in the central nervous system (CNS) …

Ischemic stroke (IS) is a major cause of morbidity and mortality worldwide, accounting for 75-
80% of all strokes. Under conditions of ischemia and hypoxia, neurons suffer damage or …