Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis

WM Wiersinga, KG Poppe… - The lancet Diabetes & …, 2023 - thelancet.com
Hyperthyroidism is a common condition with a global prevalence of 0· 2–1· 3%. When
clinical suspicion of hyperthyroidism arises, it should be confirmed by biochemical tests (eg …

Oximes: Novel therapeutics with anticancer and anti-inflammatory potential

IA Schepetkin, MB Plotnikov, AI Khlebnikov… - Biomolecules, 2021 - mdpi.com
Oximes have been studied for decades because of their significant roles as
acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have …

Sporadic medullary thyroid carcinoma: towards a precision medicine

A Matrone, C Gambale, A Prete, R Elisei - Frontiers in endocrinology, 2022 - frontiersin.org
Medullary thyroid carcinoma (MTC) is a neuroendocrine malignant tumor originating from
parafollicular C-cells producing calcitonin. Most of cases (75%) are sporadic while the …

Novel inhibitor-based therapies for thyroid cancer—An update

M Ratajczak, D Gaweł, M Godlewska - International journal of molecular …, 2021 - mdpi.com
Thyroid cancers (TCs) are the most common tumors of the endocrine system and a constant
rise in the number of TC cases has been observed for the past few decades. TCs are one of …

Endocrine-related adverse conditions induced by tyrosine kinase inhibitors

S De Leo, M Trevisan, C Moneta, C Colombo - Annales d'Endocrinologie, 2023 - Elsevier
Tyrosine kinase inhibitors (TKIs) have improved outcome for many tumors. Although better
tolerated than cytotoxic chemotherapy, they may cause several adverse events (AEs) and …

Molecular genetics of follicular-derived thyroid cancer

E Macerola, AM Poma, P Vignali, A Basolo, C Ugolini… - Cancers, 2021 - mdpi.com
Simple Summary Thyroid tumors that derive from follicular cells are not a homogeneous
entity, showing variable morphological appearance and different degrees of differentiation …

Transethosome‐Based Topical Administration Systems with Enhanced Penetration and Dual Actions for Treating EGFR‐Overexpressed Cutaneous Squamous Cell …

W Wang, PH Tham, C Ding, P Huang… - Advanced Functional …, 2024 - Wiley Online Library
Epidermal growth factor receptor (EGFR)‐overexpressing cutaneous squamous cell
carcinoma (CSCC) necessitates more effective therapies due to its elevated metastasis risk …

The influence of sunitinib and sorafenib, two tyrosine kinase inhibitors, on development and thyroid system in zebrafish larvae

G Wei, C Zhang, Y Jing, X Chen, H Song, L Yang - Chemosphere, 2022 - Elsevier
Recently, the potential toxic effects of various pharmaceuticals on the thyroid endocrine
system have raised considerable concerns. In this study, we evaluated the adverse effects of …

Recent development of VEGFR small molecule inhibitors as anticancer agents: A patent review (2021–2023)

J Zeng, Q Deng, Z Chen, S Yan, Q Dong, Y Zhang… - Bioorganic …, 2024 - Elsevier
VEGFR, a receptor tyrosine kinase inhibitor (TKI), is an important regulatory factor that
promotes angiogenesis and vascular permeability. It plays a significant role in processes …

Predictive biomarkers in thyroid cancer

E Macerola, AM Poma, P Vignali, A Proietti… - Frontiers in …, 2022 - frontiersin.org
In molecular pathology, predictive biomarkers identify which patients are likely to respond to
targeted drugs. These therapeutic agents block specific molecules directly involved in …