In two decades of development, impressive strides have been made for automating basic
laboratory operations in droplet-based microfluidics, allowing the emergence of a new form …

DNA‐encoded library (DEL) technologies are transforming the drug discovery process,
enabling the identification of ligands at unprecedented speed and scale. DEL makes use of …

Robotic high-throughput compound screening (HTS) and, increasingly, DNA-encoded
library (DEL) screening are driving bioactive chemical matter discovery in the postgenomic …

Conspectus The Human Genome Project ultimately aimed to translate DNA sequence into
drugs. With the draft in hand, the Molecular Libraries Program set out to prosecute all …

Synthetic biology relies on engineering cells to have desirable properties, such as the
production of select chemicals. A bottleneck in engineering methods is often the need to …

Three-dimensional (3D) hydrogel microspheres have aroused increasing attention as an in
vitro cell culture model. Yet the preservation of cells' original biological properties has been …

DNA-encoded library (DEL) technology is emerging as a key element of the small molecule
discovery toolbox. Conventional DEL screens (ie, on-DNA screening) interrogate large …

Combinatorial library screening increasingly explores chemical space beyond the Ro5
(bRo5), which is useful for investigating” undruggable” targets but suffers compromised …

Small molecule probes exist for only∼ 2% of human proteins because most lack functional
binding pockets or cannot be assayed for high-throughput screening. Selective translation …

Activity-based probes have greatly improved our understanding of the intrinsic roles and
expression levels of various proteins within cells. To be useful in live cells, probes must be …