With the launch of the National Institute of Child Health and Human Development/National
Institutes of Health Human Placenta Project, the anticipation is that this often-overlooked …

Imprinted genes play crucial roles in mammalian development and disruption of their
expression is associated with many human disorders including tumourigenesis; yet, the …

Background Disease risk and incidence between males and females reveal differences, and
sex is an important component of any investigation of the determinants of phenotypes or …

The rapid growth of sequencing technologies has greatly contributed to our understanding
of human genetics. Yet, despite this growth, mainstream technologies have not been fully …

In recent years, it has become increasingly clear that epigenetic regulation of gene
expression is critical during embryo development and subsequently during pre-and post …

The placenta acts not only as a conduit of nutrient and waste exchange between mother and
developing fetus, but also functions as a regulator of the intrauterine environment. Recent …

Stochastic and deterministic allele specific gene expression (ASE) might influence single
cell phenotype, but the extent and nature of the phenomenon at the onset of early mouse …

Genomic imprinting characterizes genes with a monoallelic expression, which is dependent
on the parental origin of each allele. Approximately 150 imprinted genes are known to date …

Many questions about the regulation, functional specialization, computational prediction,
and evolution of genomic imprinting would be better addressed by having an exhaustive …

BACKGROUND Analysis of circulating RNA in the plasma of pregnant women has the
potential to serve as a powerful tool for noninvasive prenatal testing and research. However …