Integrator is a global promoter-proximal termination complex
Integrator is a metazoan-specific protein complex capable of inducing termination at all
RNAPII-transcribed loci. Integrator recognizes paused, promoter-proximal RNAPII and …
RNAPII-transcribed loci. Integrator recognizes paused, promoter-proximal RNAPII and …
[HTML][HTML] Take a break: Transcription regulation and RNA processing by the Integrator complex
K Sabath, S Jonas - Current Opinion in Structural Biology, 2022 - Elsevier
The metazoan-specific Integrator complex is a> 1.5 MDa machinery that interacts with RNA
polymerase II (RNAP2) to attenuate coding gene transcription by early termination close to …
polymerase II (RNAP2) to attenuate coding gene transcription by early termination close to …
Bi-allelic variants in INTS11 are associated with a complex neurological disorder
The Integrator complex is a multi-subunit protein complex that regulates the processing of
nascent RNAs transcribed by RNA polymerase II (RNAPII), including small nuclear RNAs …
nascent RNAs transcribed by RNA polymerase II (RNAPII), including small nuclear RNAs …
Structural basis of Integrator-dependent RNA polymerase II termination
The Integrator complex can terminate RNA polymerase II (Pol II) in the promoter-proximal
region of genes. Previous work has shed light on how Integrator binds to the paused …
region of genes. Previous work has shed light on how Integrator binds to the paused …
Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function
INTS11 and CPSF73 are metal-dependent endonucleases for Integrator and pre-mRNA 3′-
end processing, respectively. Here, we show that the INTS11 binding partner …
end processing, respectively. Here, we show that the INTS11 binding partner …
Drug discovery inspired by bioactive small molecules from nature
S Kim, SW Lim, J Choi - Animal Cells and Systems, 2022 - Taylor & Francis
Natural products (NPs) have greatly contributed to the development of novel treatments for
human diseases such as cancer, metabolic disorders, and infections. Compared to synthetic …
human diseases such as cancer, metabolic disorders, and infections. Compared to synthetic …
The anticancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery
JTE-607 is an anticancer and anti-inflammatory compound and its active form, compound 2,
directly binds to and inhibits CPSF73, the endonuclease for the cleavage step in pre …
directly binds to and inhibits CPSF73, the endonuclease for the cleavage step in pre …
Emerging insights into the function and structure of the Integrator complex
MM Pfleiderer, WP Galej - Transcription, 2021 - Taylor & Francis
The Integrator was originally discovered as a specialized 3'-end processing endonuclease
complex required for maturation of RNA polymerase II (RNAPII)-dependent small nuclear …
complex required for maturation of RNA polymerase II (RNAPII)-dependent small nuclear …
Structural basis of the Integrator complex assembly and association with transcription factors
M Razew, A Fraudeau, MM Pfleiderer, R Linares… - Molecular Cell, 2024 - cell.com
Integrator is a multi-subunit protein complex responsible for premature transcription
termination of coding and non-coding RNAs. This is achieved via two enzymatic activities …
termination of coding and non-coding RNAs. This is achieved via two enzymatic activities …
SUMO conjugation regulates the activity of the Integrator complex
L Bragado, M Magalnik, P Mammi… - Nucleic Acids …, 2022 - academic.oup.com
Abstract RNA polymerase II (RNAPII) transcribes small nuclear RNA (snRNA) genes in close
proximity to Cajal bodies, subnuclear compartments that depend on the SUMO isopeptidase …
proximity to Cajal bodies, subnuclear compartments that depend on the SUMO isopeptidase …