mRNA vaccine platforms present numerous advantages, such as versatility, rapid
production, and induction of cellular and humoral responses. Moreover, mRNAs have …

Recent studies on intracellular metabolism in dendritic cells (DCs) and macrophages
provide new insights on the functioning of these critical controllers of innate and adaptive …

While many disease-associated variants have been identified through genome-wide
association studies, their downstream molecular consequences remain unclear. To identify …

The innate immune system is central for the maintenance of tissue homeostasis and quickly
responds to local or systemic perturbations by pathogenic or sterile insults. This rapid …

The immune system is tasked with identifying malignant cells to eliminate or prevent cancer
spread. This involves a complex orchestration of many immune cell types that together …

The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages
in some patients, immunoparalysis may be encountered, which is associated with a poor …

It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …

The past 15 years have seen enormous advances in our understanding of the receptor and
signalling systems that allow dendritic cells (DCs) to respond to pathogens or other danger …

Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes
them to undergo a metabolic switch towards glycolysis and away from oxidative …

Toll-like receptor (TLR) agonists demonstrate therapeutic promise as immunological
adjuvants for anticancer immunotherapy. To date, three TLR agonists have been approved …