Significance: Under homeostatic conditions, the endothelium dynamically regulates vascular
barrier function, coagulation pathways, leukocyte adhesion, and vasomotor tone. During …

Infections represent a common health problem in people of all ages. Usually, the response
given to them is appropriate and so little treatment is needed. Sometimes, however, the …

Background Intravenous fluids are recommended for the treatment of patients who are in
septic shock, but higher fluid volumes have been associated with harm in patients who are …

Although guidelines provide excellent expert guidance for managing patients with septic
shock, they leave room for personalization according to patients' condition. Hemodynamic …

Purpose We assessed the effects of a protocol restricting resuscitation fluid vs. a standard
care protocol after initial resuscitation in intensive care unit (ICU) patients with septic shock …

Purpose Shock is a life-threatening condition characterized by substantial alterations in the
microcirculation. This study tests the hypothesis that considering sublingual microcirculatory …

Introduction Inadequate initial treatment and delayed hemodynamic stabilization (HDS) may
be associated with increased risk of death in severe sepsis patients. Methods In order to …

Sepsis is one of the main reasons for intensive care unit admission and is responsible for
high morbidity and mortality. The usual hemodynamic targets for resuscitation of patients …

Background During septic shock management, the evaluation of microvascular perfusion by
skin analysis is of interest. We aimed to study the skin capillary refill time (CRT) in a selected …

Introduction Acute circulatory dysfunction in patients with sepsis can evolve rapidly into a
progressive stage associated with high mortality. Early recognition and adequate …