With the alarming increase of infections caused by pathogenic multidrug-resistant bacteria
over the last decades, antimicrobial peptides (AMPs) have been investigated as a potential …

The goal of genomics and systems biology is to understand how complex systems of factors
assemble into pathways and structures that combine to form living organisms. Great …

Colonization of the gastrointestinal (GI) tract by Klebsiella pneumoniae is generally
considered asymptomatic. However, gut colonization allows K. pneumoniae to either …

Streptococcus pneumoniae (Spn) colonizes the nasopharynx and can cause pneumonia.
From the lungs it spreads to the bloodstream and causes organ damage. We characterized …

Abstract Vaccines targeting Streptococcus pneumoniae (Spn) are limited by dependence on
capsular polysaccharide and its serotype diversity. More broadly-based approaches using …

Successful colonization of a host requires bacterial adaptation through genetic and
population changes that are incompletely defined. Using chromosomal barcoding and high …

Small animal models have been a challenge for the study of SARS-CoV-2 transmission, with
most investigators using golden hamsters or ferrets. Mice have the advantages of low cost …

Staphylococcus aureus is an important pathogen that leads to high morbidity and mortality.
Although S. aureus produces many factors important for pathogenesis, few have been …

Streptococcus pneumoniae (also called pneumococcus) is not only a commensal that
frequently colonizes the human upper respiratory tract but also a pathogen that causes …

How directly transmitted pathogens benefit from harming hosts is key to understanding
virulence evolution. It is recognized that pathogens benefit from high within-host loads, often …