Rhoptries are specialized secretory organelles found in the Apicomplexa phylum, playing a
central role in the establishment of parasitism. The rhoptry content includes membranous as …

In the last 10 years, proximity‐dependent biotinylation (PDB) techniques greatly expanded
the ability to study protein environments in the living cell that range from specific protein …

Malaria is caused by infection of the erythrocytes by the parasites Plasmodium. Inside the
erythrocytes, the parasites multiply via schizogony, an unconventional cell division mode …

Taxon-specific proteins are key determinants defining the biology of all organisms and
represent prime drug targets in pathogens. However, lacking comparability with proteins in …

Single amino acid changes in the parasite protein Kelch13 (K13) result in reduced
susceptibility of P. falciparum parasites to artemisinin and its derivatives (ART). Recent work …

The inner membrane complex (IMC) is a defining feature of apicomplexan parasites, which
confers stability and shape to the cell, functions as a scaffolding compartment during the …

The disease-causing blood-stage of the Plasmodium falciparum lifecycle begins with
invasion of human erythrocytes by merozoites. Many vaccine candidates with key roles in …

Mature gametocytes of Plasmodium falciparum display a banana (falciform) shape conferred
by a complex array of subpellicular microtubules (SPMT) associated with the inner …

Membrane transport proteins perform crucial roles in cell physiology. The obligate
intracellular parasite Plasmodium falciparum, an agent of human malaria, relies on …

The interaction of Plasmodium falciparum—infected red blood cells (iRBCs) with the
vascular endothelium plays a crucial role in malaria pathology and disease. KAHRP is an …