Autoimmune diseases generally result from the loss of self-tolerance (ie, failure of the
immune system to distinguish self from non-self), and are characterized by autoantibody …

Patients with adult‐onset autoimmune diabetes have less Human Leucocyte Antigen (HLA)‐
associated genetic risk and fewer diabetes‐associated autoantibodies compared with …

OBJECTIVE Latent autoimmune diabetes in adults (LADA) shares clinical features with both
type 1 and type 2 diabetes; however, there is ongoing debate regarding the precise …

The pathogenesis of autoimmunity remains to be fully elucidated, although the contribution
of genetic and environmental factors is generally recognized. Despite autoimmune …

Patients with Type 2 diabetes (T2D) are highly susceptible to infection and have an
increased incidence of some tumors, possibly due to immune system dysfunction. In the …

OBJECTIVE B lymphocytes play an important role in the immunopathogenesis of
autoimmune diabetes. We hypothesized that the altered B-cell subset phenotype is …

HIV-1 broadly neutralizing antibodies (bnAbs) are difficult to induce with vaccines but are
generated in∼ 50% of HIV-1-infected individuals. Understanding the molecular …

Epidemiological studies have indicated that obesity is associated with a higher risk for
certain cancers caused by elevated levels of adipocyte-derived hormones. Leptin, one such …

The immunopathology of type I diabetes (T1D) presents a complicated case in part because
of the multifactorial origin of this disease. Typically, T1D is thought to occur as a result of …

Recurrent pregnancy loss (RPL) is a common complication in obstetrics, affecting about 5%
of women of childbearing age. An increase in the number of abortions results in escalation …