Targeting SREBP-1-mediated lipogenesis as potential strategies for cancer
Q Zhao, X Lin, G Wang - Frontiers in oncology, 2022 - frontiersin.org
Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic
helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from …
helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from …
Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers
Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …
Orchestral role of lipid metabolic reprogramming in T-cell malignancy
The immune function of normal T cells partially depends on the maneuvering of lipid
metabolism through various stages and subsets. Interestingly, T-cell malignancies also …
metabolism through various stages and subsets. Interestingly, T-cell malignancies also …
Generation and multiomic profiling of a TP53/CDKN2A double-knockout gastroesophageal junction organoid model
Inactivation of the tumor suppressor genes tumor protein p53 (TP53) and cyclin-dependent
kinase inhibitor 2A (CDKN2A) occurs early during gastroesophageal junction (GEJ) …
kinase inhibitor 2A (CDKN2A) occurs early during gastroesophageal junction (GEJ) …
Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection
Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely
unknown due to the biases of previous large-scale studies toward pro-viral host factors. To …
unknown due to the biases of previous large-scale studies toward pro-viral host factors. To …
Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells
M Hazawa, DK Ikliptikawati, Y Iwashima, DC Lin… - Cell Chemical …, 2024 - cell.com
Master transcription factors such as TP63 establish super-enhancers (SEs) to drive core
transcriptional networks in cancer cells, yet the spatiotemporal regulation of SEs within the …
transcriptional networks in cancer cells, yet the spatiotemporal regulation of SEs within the …
Fatty acid synthase is the key regulator of fatty acid metabolism and is related to immunotherapy in bladder cancer
Fatty acid metabolism (FAM) genes are potentially useful for predicting prognosis and
immunotherapy response in bladder cancer (BC). To examine this, we constructed a …
immunotherapy response in bladder cancer (BC). To examine this, we constructed a …
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability
X Chen, H Yong, M Chen, C Deng, P Wang… - Journal of Experimental …, 2023 - Springer
Background Metabolic reprogramming is a hallmark of various cancers. Targeting metabolic
processes is a very attractive treatment for cancer. Renal cell carcinoma (RCC) is a type of …
processes is a very attractive treatment for cancer. Renal cell carcinoma (RCC) is a type of …
Baicalein enhances immune response in TNBC by inhibiting leptin expression of adipocytes
M Liu, C Li, J Qu, S Sun, Z Zhao, W Wang, W Lv… - Cancer …, 2023 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is a special pathological type of breast cancer (BC)
with poor prognosis. Obesity is shown to be involved in TNBC tumor progression. The …
with poor prognosis. Obesity is shown to be involved in TNBC tumor progression. The …
Computational identification of preneoplastic cells displaying high stemness and risk of cancer progression
Evidence points toward the differentiation state of cells as a marker of cancer risk and
progression. Measuring the differentiation state of single cells in a preneoplastic population …
progression. Measuring the differentiation state of single cells in a preneoplastic population …