Ten principles of heterochromatin formation and function

RC Allshire, HD Madhani - Nature reviews Molecular cell biology, 2018 - nature.com
Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …

RNA-mediated epigenetic regulation of gene expression

D Holoch, D Moazed - Nature Reviews Genetics, 2015 - nature.com
Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key
regulators of gene expression, genome stability and defence against foreign genetic …

Epigenetic inheritance uncoupled from sequence-specific recruitment

K Ragunathan, G Jih, D Moazed - Science, 2015 - science.org
INTRODUCTION Changes in histone posttranslational modifications are associated with
epigenetic states that define distinct patterns of gene expression. Whereas sequence …

Small RNAs in the transgenerational inheritance of epigenetic information

L Duempelmann, M Skribbe, M Bühler - Trends in Genetics, 2020 - cell.com
In recent years it has become evident that RNA interference-related mechanisms can
mediate the deposition and transgenerational inheritance of specific chromatin modifications …

Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription

G Jih, N Iglesias, MA Currie, NV Bhanu, JA Paulo… - Nature, 2017 - nature.com
Heterochromatic DNA domains have important roles in the regulation of gene expression
and maintenance of genome stability by silencing repetitive DNA elements and transposons …

Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation

R Yu, X Wang, D Moazed - Nature, 2018 - nature.com
Histone post-translational modifications (PTMs) are associated with epigenetic states that
form the basis for cell-type-specific gene expression,. Once established, histone PTMs can …

An essential role for the piRNA pathway in regulating the ribosomal RNA pool in C. elegans

L Wahba, L Hansen, AZ Fire - Developmental cell, 2021 - cell.com
Piwi-interacting RNAs (piRNAs) are RNA effectors with key roles in maintaining genome
integrity and promoting fertility in metazoans. In Caenorhabditis elegans loss of piRNAs …

Dicer promotes transcription termination at sites of replication stress to maintain genome stability

SE Castel, J Ren, S Bhattacharjee, AY Chang… - Cell, 2014 - cell.com
Nuclear RNAi is an important regulator of transcription and epigenetic modification, but the
underlying mechanisms remain elusive. Using a genome-wide approach in the fission yeast …

The Paf1 complex represses small-RNA-mediated epigenetic gene silencing

KM Kowalik, Y Shimada, V Flury, MB Stadler, J Batki… - Nature, 2015 - nature.com
RNA interference (RNAi) refers to the ability of exogenously introduced double-stranded
RNA to silence expression of homologous sequences. Silencing is initiated when the …

Non-coding RNAs and transposable elements in plant genomes: emergence, regulatory mechanisms and roles in plant development and stress responses

J Hou, D Lu, AS Mason, B Li, M Xiao, S An, D Fu - Planta, 2019 - Springer
Main conclusion This review will provide evidence for the indispensable function of these
elements in regulating plant development and resistance to biotic and abiotic stresses, as …