RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …

Cancer was initially considered to be an exclusively genetic disease, but an interplay of
dysregulated genetic and epigenetic mechanisms is now known to contribute to the cancer …

Chromothripsis is a catastrophic mutational process that promotes tumorigenesis and
causes congenital disease,,–. Chromothripsis originates from aberrations of nuclei called …

Prolonged pausing of the transcription machinery may lead to the formation of three-
stranded nucleic acid structures, called R-loops, typically resulting from the annealing of the …

The family of adenosine deaminases acting on RNA (ADARs) regulates global gene
expression output by catalyzing adenosine-to-inosine (A-to-I) editing of double-stranded …

Cardiovascular disease (CVD) is the leading cause of death in the world, with a high
incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable …

At critically short telomeres, stabilized TERRA RNA-DNA hybrids drive homology-directed
repair (HDR) to delay replicative senescence. However, even at long-and intermediate …

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

Double‐strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell
proliferation and genome integrity. Depending on cell cycle stage, DSBs are preferentially …

Genomic instability poses a formidable threat to cellular vitality and wellbeing, prompting
cells to deploy an intricate DNA damage response (DDR) mechanism. Recent evidence has …