Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

The complement membrane attack complex (MAC) is classically known as a cytolytic effector
of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or …

Cardiac allograft vasculopathy (CAV) is a pathologic immune-mediated remodelling of the
vasculature in transplanted hearts and, by impairing perfusion, is the major cause of late …

Abstract Antibody-mediated rejection (AMR), including chronic AMR (cAMR), causes~ 50%
of kidney allograft losses each year. Despite attempts to develop well-tolerated and effective …

Transplantation is an effective approach for treating end-stage organ failure. There has been
a long-standing interest in xenotransplantation as a means of increasing the number of …

Kidneys from donation after circulatory death (DCD) donors are utilized variably worldwide,
in part due to high rates of delayed graft function (DGF) and putative associations with …

Previous studies on immune responses following COVID-19 vaccination in patients with
common variable immunodeficiency (CVID) were inconclusive with respect to the ability of …

The zinc finger protein ZFYVE21 is involved in immune signaling. Using humanized mouse
models, primary human cells, and patient samples, we identified a T cell–autonomous role …

Background Innate immunity plays a fundamental role in solid organ transplantation.
Myeloid cells can sense danger signals or DAMPs released after tissue or cell damage …

Kidney transplantation is a life-saving strategy for patients with end-stage renal disease.
Although progress has been made in the field of transplantation medicine in recent decades …