▪ Abstract GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by
increasing the rates at which their α subunits hydrolyze bound GTP and thus return to the …

Regulators of G protein signaling (RGS) and RGS-like proteins are a family (> 30 members)
of highly diverse, multifunctional signaling proteins that bind directly to activated Gα …

Polycystic kidney disease (PKD), a common genetic cause of chronic renal failure in
children and adults, is characterized by the accumulation of fluid-filled cysts in the kidney …

Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G
protein–coupled receptor signaling pathways. The major mechanism whereby RGS proteins …

Primary cilia are implicated in the pathogenesis of autosomal-dominant polycystic kidney
disease (ADPKD), which results from defects in polycystin-1 (PC1), but the function of PC1 …

Molecular pathogenesis of ADPKD: The polycystin complex gets complex. Autosomal-
dominant polycystic kidney disease (ADPKD) is one of the most common human monogenic …

The trafficking of ion channels to the plasma membrane is tightly controlled to ensure the
proper regulation of intracellular ion homeostasis and signal transduction. Mutations of …

Polycystins are a family of eight-transmembrane proteins united by sequence homology.
The name stems from the identification of mutations in genes encoding polycystin-1 and-2 in …

Regulators of G-protein signalling (RGS proteins) are a family of highly diverse,
multifunctional signalling proteins that share a conserved 120 amino acid domain (RGS …

Autosomal dominant polycystic kidney disease (ADPKD) is a common human genetic
disease characterized by cyst formation in kidney tubules and other ductular epithelia. Cells …