The immune system protects the host from pathogenic organisms (bacteria, viruses, fungi,
parasites). To deal with this array of threats, the immune system has evolved to include a …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

In electrically nonexcitable cells, Ca2+ influx is essential for regulating a host of kinetically
distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and …

The TRP (“transient receptor potential”) family of ion channels now comprises more than 30
cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the …

It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …

Recent breakthroughs in the store-operated calcium (Ca2+) entry (SOCE) pathway have
identified Stim1 as the endoplasmic reticulum Ca2+ sensor and Orai1 as the pore forming …

Pulmonary vascular medial hypertrophy caused by excessive pulmonary artery smooth
muscle cell (PASMC) proliferation is a major cause for the elevated pulmonary vascular …

Chronic hypoxia (CH) causes pulmonary vasoconstriction because of increased pulmonary
arterial smooth muscle cell (PASMC) contraction and proliferation. We previously …

Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of
Transient Receptor Potential (TRP), a Ca2+-permeable channel involved in the …