Cancer immunotherapy has become a new generation of anti-tumor treatment, but its
indications still focus on several types of tumors that are sensitive to the immune system …

Epithelial to mesenchymal transition (EMT) contributes to tumor progression, cancer cell
invasion, and therapy resistance. EMT is regulated by transcription factors such as the …

The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …

Hepatocellular carcinoma (HCC) has been identified as one of the most deadly
malignancies with limited therapeutic efficacy worldwide. However, understanding the …

The rise of cancer immunotherapy, particularly the use of immune checkpoint inhibitors
(ICIs), has significantly changed the clinical treatment paradigm for patients with cancer. The …

Signal transducer and activator of transcription 3 (STAT3) has a prominent role in mediating
resistance to conventional chemo-/radio-therapies and modern targeted drugs. While a …

Cisplatin is one of the most frequently used chemotherapeutic agents for treatment of a wide
range of cancer types. Nevertheless, the intrinsic or acquired resistance to cisplatin remains …

The interaction of immune checkpoint molecules in the tumor microenvironment reduces the
anti-tumor immune response by suppressing the recognition of T cells to tumor cells …

COVID-19, the illness caused by infection with the novel coronavirus SARS-CoV-2, is a
rapidly spreading global pandemic in urgent need of effective treatments. Here we present a …

Anti-neoplastic agents for cancer treatment utilize many different mechanisms of action and,
when combined, can result in potent inhibition of cancer growth. Combination therapies can …