The remarkable capacity of some viruses to adapt to new hosts and environments is highly
dependent on their ability to generate de novo diversity in a short period of time. Rates of …

The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

The COVID-19 outbreak has become a global health risk, and understanding the response
of the host to the SARS-CoV-2 virus will help to combat the disease. RNA editing by host …

Rates of spontaneous mutation critically determine the genetic diversity and evolution of
RNA viruses. Although these rates have been characterized in vitro and in cell culture …

Several novel anti-influenza compounds are in various phases of clinical development. One
of these, T-705 (favipiravir), has a mechanism of action that is not fully understood but is …

Summary The 2013–2015 Ebola virus disease (EVD) epidemic is caused by the Makona
variant of Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights …

A-to-I RNA editing, the deamination of adenosine (A) to inosine (I) that occurs in regions of
RNA with double-stranded character, is catalyzed by a family of Adenosine Deaminases …

Post-transcriptional modifications have been recently expanded with the addition of RNA
editing, which is predominantly mediated by adenosine and cytidine deaminases acting on …

The nucleoside inosine plays an important role in purine biosynthesis, gene translation, and
modulation of the fate of RNAs. The editing of adenosine to inosine is a widespread post …

Adenosine deaminases acting on RNA (ADAR) are RNA-editing enzymes that may restrict
viral infection. We have utilized deep sequencing to determine adenosine to guanine (A→ …