Since the update of the 4th edition of the WHO Classification of Central Nervous System
(CNS) Tumors published in 2016, particular molecular characteristics are part of the …

The mutational landscape of meningioma has expanded following the use of the new
genetic sequencing approaches. Novel mutations have been characterized and reveal their …

In the 5th edition of the WHO CNS tumor classification (CNS5, 2021), multiple molecular
characteristics became essential diagnostic criteria for many additional CNS tumor types …

Background There is a critical need for objective and reliable biomarkers of outcome in
meningiomas beyond WHO classification. Loss of H3K27me3 has been reported as a …

Background: Serpin peptidase inhibitor clade H, member 1 (SERPINH1) is a gene encoding
a member of the serpin superfamily of serine proteinase inhibitors. The upregulated of …

Meningioma is the most common primary intracranial tumor in adults. The grading of
meningioma is based on World Health Organization criteria, which rely on histopathological …

Meningiomas are the most common primary intracranial tumor with current classification
offering limited therapeutic guidance. Here, we interrogated meningioma enhancer …

Homozygous deletion of CDKN2A/B was recently incorporated into the World Health
Organization classification for grade 3 meningiomas. While this marker is overall rare in …

High‐grade meningioma has an unsatisfactory outcome despite surgery and postoperative
radiotherapy; however, the factors driving its malignancy and recurrence remain largely …

Introduction The extent of meningioma resection is the most fundamental risk factor for
recurrence, and exact knowledge of extent of resection is necessary for prognostication and …