Nucleic acid comprising or coding for a histone stem-loop and a poly (A) sequence or a polyadenylation signal for increasing the expression of an encoded …
A Thess, T Schlake, J Probst - US Patent 9,669,089, 2017 - Google Patents
The present invention relates to a nucleic acid sequence, comprising or coding for a coding
region, encoding at least one peptide or protein comprising a pathogenic antigen or a …
region, encoding at least one peptide or protein comprising a pathogenic antigen or a …
System for targeted delivery of therapeutic agents
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M1kose1a1. 6,403,779 B1 6/2002 Kawasakl et al. 5,514,378 A 5/1996 M1koseta1 …
Artificial nucleic acid molecules
A Thess - US Patent 10,047,375, 2018 - Google Patents
The invention relates to an artificial nucleic acid molecule comprising at least one open
reading frame and at least one 3′-untranslated region element (3′-UTR) element …
reading frame and at least one 3′-untranslated region element (3′-UTR) element …
Nucleic acid comprising or coding for a histone stem-loop and a poly (A) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic …
A Thess, T Schlake, J Probst - US Patent 10,232,024, 2019 - Google Patents
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2/2013 Ketterer et al. 8, 703, 906 B2 4/2014 Baumhof et al. 8, 968, 746 B2 3/2015 Baumhof …
Artificial nucleic acid molecules comprising a 5′ TOP UTR
A Thess - US Patent 10,080,809, 2018 - Google Patents
The invention relates to an artificial nucleic acid molecule comprising at least one 5′ UTR
element which is derived from a TOP gene, at least one open reading frame and optionally …
element which is derived from a TOP gene, at least one open reading frame and optionally …
Vaccine nanotechnology
2008-11-17 Assigned to THE BRIGHAM AND WOMEN'S HOSPITAL, INC. reassignment
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ASSIGNMENT OF ASSIGNORS …
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ASSIGNMENT OF ASSIGNORS …
Vaccine nanotechnology
2013-03-26 Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGY reassignment
MASSACHUSETTS INSTITUTE OF TECHNOLOGY ASSIGNMENT OF ASSIGNORS …
MASSACHUSETTS INSTITUTE OF TECHNOLOGY ASSIGNMENT OF ASSIGNORS …
Nucleic acid comprising or coding for a histone stem-loop and a poly (A) sequence or a polyadenylation signal for increasing the expression of an encoded tumour …
A Thess, T Schlake, J Probst - US Patent 10,010,592, 2018 - Google Patents
The present invention relates to a nucleic acid sequence, comprising or coding for a coding
region, encoding at least one peptide or protein comprising a tumor antigen or a fragment …
region, encoding at least one peptide or protein comprising a tumor antigen or a fragment …
Artificial nucleic acid molecules
S Grund, T Schlake - US Patent 11,697,816, 2023 - Google Patents
The invention relates to an artificial nucleic acid molecule comprising at least one open
reading frame and at least one 3′-untranslated region element (3′-UTR element) …
reading frame and at least one 3′-untranslated region element (3′-UTR element) …
Polymers for functional particles
The present invention generally relates to polymers and mac romolecules, in particular, to
block polymers useful in par ticles Such as nanoparticles. One aspect of the invention is …
block polymers useful in par ticles Such as nanoparticles. One aspect of the invention is …