Mitochondria-associated endoplasmic reticulum membranes (MAMs) are dynamic
membrane coupling regions formed by the coupling of the mitochondrial outer membrane …

Oxidative stress is an imbalance between free radicals and the antioxidant system causing
overgeneration of free radicals (oxygen‐containing molecules) ultimately leading to …

Autophagy and apoptosis represent two fundamental pathophysiological mechanisms of cell
fate regulation. However, the signaling pathways of these processes are significantly …

Myocardial infarction is one of the primary causes of mortality in patients with coronary heart
disease worldwide. Early treatment of acute myocardial infarction restores blood supply of …

Predisposition to Alzheimer's disease (AD) may arise from lipid metabolism perturbation,
however, the underlying mechanism remains elusive. Here, we identify ATPase family AAA …

Sarcopenia is a severe loss of muscle mass and functional decline during aging that can
lead to reduced quality of life, limited patient independence, and increased risk of falls. The …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member
of the PARP superfamily, with its primary function being the facilitation of DNA damage …

Intrinsic disorder is a natural feature of polypeptide chains, resulting in the lack of a defined
three-dimensional structure. Conformational changes in intrinsically disordered regions of a …

Lysosome-mediated autophagy and caspase-dependent apoptosis are dynamic processes
that maintain cellular homeostasis, ensuring cell health and functionality. The intricate …

Rationale: Glioblastoma (GBM) is the most common and malignant primary brain tumor in
adults. Radiotherapy has long been an important treatment for GBM. Despite recent …