In the drug delivery system, the transdermal drug delivery system has the advantages of
painless administration, avoiding the first-pass metabolism, sustained therapeutic effect, and …

Highlights•pH is vital for the normal functioning of the body.•Drug targeting has been widely
used to increase efficacy and reduce adverse effects.•pH variation in different tissues and …

Chemotherapeutic cytotoxic agents such as paclitaxel (PTX) are considered essential for the
treatment of various cancers. However, PTX injection is associated with severe systemic …

Nanocarriers and nanoparticles in the drug delivery systems increase the drug's
effectiveness due to their permeability and retention properties to tumor tissues. Exosomes …

Triple-negative breast cancer (TNBC) does not respond to HER2-targeted and hormone-
based medicines. Epidermal growth factor receptor 1 (EGFR1) is commonly overexpressed …

Ionic liquids (ILs) are composed of asymmetric cationic and anionic moieties and are used
as green solvents. Their non-toxic nature, favorable biocompatibility and adjustable structure …

In this study, a nanocarrier was prepared for targeted delivery of doxorubicin (DOX), as a
drug model, to cancer cells. To this end, nontoxic Fe 3 O 4 nanoparticles (NPs) were first …

Ionic liquids (ILs) have a long and successful history of application as materials of special
interest in various fields, particularly in biomedicine. When polymerized at the nanoscale …

Background Drug combination therapy is preferred over monotherapy in clinical research to
improve therapeutic effects. Developing a new nanodelivery system for cancer drugs can …

Abstract 'Active targeting'refers to modifying a nanocarrier's surface with targeting ligands.
This study introduced an efficient approach for immobilizing imidazole-based drugs onto the …