Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following
a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive …

CD8+ T cells belonging to the adaptive immune system play key roles in defending against
viral infections and cancers. The current CD8+ T cell-based immunotherapy has emerged as …

Vaccination strategies against mycobacteria, focusing mostly on classical T‐and B‐cells,
have shown limited success, encouraging the addition of alternative targets. Classically …

Bioorthogonal deprotections are readily used to control biological function in a cell-specific
manner. To further improve the spatial resolution of these reactions, we here present a …

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected
cells and prevent malaria, but simple vaccines for generating this important immune …

Introduction Vaccination can be effective defense against many infectious agents and the
corresponding diseases. Discoveries elucidating the mechanisms of the immune system …

Natural killer T (NKT) cells are a population of innate-like T cells capable of enhancing both
innate and adaptive immune responses. Co-delivering an NKT cell agonist and antigen can …

Self-adjuvanting vaccines consisting of peptide epitopes conjugated to immune adjuvants
are a powerful way of generating antigen-specific immune responses. We previously …

Eliciting an antihapten antibody response to vaccination typically requires the use of
constructs where multiple copies of the hapten are covalently attached to a larger carrier …

The capacity of α-galactosylceramide (α-GalCer) to act as an anti-cancer agent in mice
through the specific stimulation of type I NKT (iNKT) cells has prompted extensive …