Arylglyoxals in synthesis of heterocyclic compounds

B Eftekhari-Sis, M Zirak, A Akbari - Chemical reviews, 2013 - ACS Publications
Heterocycles are an extraordinarily important class of compounds, making up more than half
of all known organic compounds. Heterocycles are present in a wide variety of drugs, most …

1, 2, 4-Triazine chemistry part III: synthetic strategies to functionalized bridgehead nitrogen heteroannulated 1, 2, 4-triazine systems and their regiospecific and …

RM Abdel-Rahman, M ST Makki, TE Ali… - Current Organic …, 2013 - ingentaconnect.com
1,2,4-Triazine Chemistry Part III: Synthetic Strategies to Functionalized Bridgehead Nitrogen
Heteroannulated 1,2,4-Triazine Sys Page 1 Send Orders of Reprints at bspsaif@emirates.net.ae …

Synthesis, structure elucidation and identification of antitumoural properties of novel fused 1, 2, 4-triazine aryl derivatives

K Sztanke, K Pasternak, J Rzymowska… - European journal of …, 2008 - Elsevier
Synthesis, structure elucidation and anticancer activities of novel fused 1, 2, 4-triazine aryl
derivatives containing the ethoxycarbonyl (6–10) and carbohydrazide formations (11–15) …

Pyrrolo [2, 1-c][1, 2, 4] triazines from 2-diazopyrroles: synthesis and antiproliferative activity

P Diana, P Barraja, A Lauria, A Montalbano… - European journal of …, 2002 - Elsevier
Pyrrolo [2, 1-c][1, 2, 4] triazines 4a–g were directly obtained from the reaction of 2-
diazopyrroles 1a and b with the sodium salts of β-diketones, β-carbonitriles, and β-dinitriles …

Synthesis and antitumor activity of new 1,2,4‐triazine and [1,2,4]triazolo[4,3‐b][1,2,4]triazine derivatives and their thioglycoside and acyclic C‐nucleoside analogs

WA El‐Sayed, IF Nassar… - Journal of Heterocyclic …, 2011 - Wiley Online Library
Abstract New 1, 2, 4‐triazine and their derived 1, 2, 4‐triazolo [3, 4‐b][1, 2, 4] triazine
derivatives were synthesized starting from 5, 6‐diphenyl‐1, 2, 4‐triazine‐3‐thiol …

Identification of antibacterial and antiviral activities of novel fused 1, 2, 4-triazine esters

K Sztanke, K Pasternak, B Rajtar, M Sztanke… - Bioorganic & medicinal …, 2007 - Elsevier
The in vitro biological activities of novel derivatives of methyl and ethyl 2-(4-oxo-8-aryl-2H-3,
4, 6, 7-tetrahydroimidazo [2, 1-c][1, 2, 4] triazin-3-yl) acetates (3a, 3d–j) have been evaluated …

Synthesis, crystal structure and anticancer activity of novel derivatives of ethyl 1-(4-oxo-8-aryl-4, 6, 7, 8-tetrahydroimidazo [2, 1-c][1, 2, 4] triazin-3-yl) formate

K Sztanke, J Rzymowska, M Niemczyk, I Dybała… - European journal of …, 2006 - Elsevier
Synthesis and anticancer activity of ethyl 1-(4-oxo-8-aryl-4, 6, 7, 8-tetrahydroimidazo [2, 1-
c][1, 2, 4] triazin-3-yl) formates (7–12) are presented. The title compounds were obtained by …

Isoindolo [2, 1-c] benzo [1, 2, 4] triazines: a new ring system with antiproliferative activity

P Diana, A Martorana, P Barraja, A Lauria… - Bioorganic & Medicinal …, 2007 - Elsevier
A series of isoindolo-benzo-triazines of type 4 was obtained by diazotization of 2-(2-
aminoaryl)-1-cyanoisoindoles 3a–j. All the synthesized derivatives were screened by the …

Novel derivatives of methyl and ethyl 2-(4-oxo-8-aryl-2H-3, 4, 6, 7-tetrahydroimidazo [2, 1-c][1, 2, 4] triazin-3-yl) acetates from biologically active 1-aryl-2 …

K Sztanke, J Rzymowska, M Niemczyk, I Dybała… - European journal of …, 2006 - Elsevier
The 1-aryl-2-hydrazinoimidazolines (2a–h) were directly obtained from appropriate 1-aryl-2-
methylthioimidazolines (1a–h) by condensation reaction with hydrazine hydrate …

Crystal structure, antitumour and antimetastatic activities of disubstituted fused 1, 2, 4-triazinones

K Sztanke, K Pasternak, M Sztanke… - Bioorganic & medicinal …, 2009 - Elsevier
Molecular structure of 3, 8-disubstituted 7, 8-dihydroimidazo [2, 1-c][1, 2, 4] triazin-4 (6H)-
ones (8–14) was confirmed by X-ray crystallography of 14. All the compounds were …