A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …

Background c-kit-positive, lineage-negative cardiac stem cells (CSCs) improve post-
infarction left ventricular (LV) dysfunction when administered to animals. We undertook a …

Rationale: The regenerative potential of the heart is insufficient to fully restore functioning
myocardium after injury, motivating the quest for a cell-based replacement strategy. Bone …

Rationale: Multiple biological mechanisms contribute to the efficacy of cardiac cell therapy.
Most prominent among these are direct heart muscle and blood vessel regeneration from …

This study is aimed at investigating whether human umbilical cord mesenchymal stem cell‐
(hucMSC‐) derived exosomes (hucMSC‐exosomes) have a protective effect on acute …

The mechanism (s) underlying cardiac reparative effects of bone marrow-derived
mesenchymal stem cells (MSC) remain highly controversial. Here we tested the hypothesis …

Cardiovascular diseases are known as one of major causes of morbidity and mortality
worldwide. Despite the many advancement in therapies are associated with cardiovascular …

Background—Administration of cardiac progenitor cells (CPCs) 4 hours after reperfusion
ameliorates left ventricular function in rats with acute myocardial infarction (MI). Clinically …

Multiple studies demonstrated that early growth response factor 1 (EGR1) induces
myocardial damage after acute myocardial infarction (AMI). Recent evidence indicates that …