The most significant advance in the medical management of HIV-1 infection has been the
treatment of patients with antiviral drugs, which can suppress HIV-1 replication to …

The new field of viral dynamics, based on within-host modeling of viral infections, began with
models of human immunodeficiency virus (HIV), but now includes many viral infections …

We present a new approach to the study of the immune system that combines techniques of
systems biology with information provided by data-driven prediction methods. To this end …

Although highly active antiretroviral therapy (HAART) in the form of triple combinations of
drugs including protease inhibitors can reduce the plasma viral load of some HIV-1-infected …

Mathematical models have proven valuable in understanding the dynamics of HIV-1
infection in vivo. By comparing these models to data obtained from patients undergoing …

Abstract Analysis of changes in viral load after initiation of treatment with potent antiretroviral
agents has provided substantial insight into the dynamics of human immunodeficiency virus …

Identification of the transmitted/founder virus makes possible, for the first time, a genome-
wide analysis of host immune responses against the infecting HIV-1 proteome. A complete …

T-20, a synthetic peptide corresponding to a region of the transmembrane subunit of the HIV-
1 envelope protein, blocks cell fusion and viral entry at concentrations of less than 2 ng/ml in …

The recent development of potent antiviral drugs not only has raised hopes for effective
treatment of infections with HIV or the hepatitis B virus, but also has led to important …

Models of HIV-1 infection that include intracellular delays are more accurate representations
of the biology and change the estimated values of kinetic parameters when compared to …