Plants biosynthesize a broad range of natural products through specialized and species-
specific metabolic pathways that are fuelled by core metabolism, together forming a …

How to adapt to a changing environment is a fundamental, recurrent problem confronting
cells. One solution is for cells to organize their constituents into a limited number of spatially …

Chromosomes in all domains of life are well-defined structural entities with complex
hierarchical organization. The regulation of this hierarchical organization and its functional …

The soil-dwelling filamentous bacteria, Streptomyces, is widely known for its ability to
produce numerous bioactive natural products. Despite many efforts toward their …

Introduction Natural products discovered from bacteria provide critically needed therapeutic
leads for drug discovery, and myxobacteria are an established source for metabolites with …

DNA supercoiling is central to many fundamental processes of living organisms. Its average
level along the chromosome and over time reflects the dynamic equilibrium of opposite …

Marine microorganisms produce a variety of bioactive secondary metabolites, which
represent a significant source of novel antibiotics. Heterologous expression is a valuable …

Bacterial chromosome topology is controlled by topoisomerases and nucleoid-associated
proteins (NAPs). While topoisomerases regulate DNA supercoiling, NAPs introduce bends …

Bacteria of the genus Streptomyces have a linear chromosome, with a core region and two
'arms'. During their complex life cycle, these bacteria develop multi-genomic hyphae that …

Phages are ubiquitous in nature, and bacteria with very different genomics, metabolisms,
and lifestyles are subjected to their predation. Yet, the defence systems that allow bacteria to …