Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …

Ferroptosis is recognized as a new form of regulated cell death which is initiated by severe
lipid peroxidation relying on reactive oxygen species (ROS) generation and iron overload …

Iron accumulation and neuroinflammation are pathological conditions found in several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …

Although defects in intracellular calcium homeostasis are known to play a role in the
pathogenesis of Parkinson's disease (PD), the underlying molecular mechanisms remain …

Neural tissue is one of the main oxygen consumers in the mammalian body, and a
plentitude of metabolic as well as signaling processes within the brain is accompanied by …

Abstract Ischemia/reperfusion-(I/R-) induced injury is unavoidable and a major risk factor for
graft failure and acute rejection following kidney transplantation. However, few effective …

Ferroptosis, a type of cell death involving iron and lipid peroxidation, has been found to be
closely associated with the development of many diseases. Mitochondria are vital …

NEET proteins belong to a highly conserved group of [2Fe–2S] proteins found across all
kingdoms of life. Due to their unique [2Fesingle bond2S] cluster structure, they play a key …

Pioglitazone, an FDA-approved compound, has been shown to target the novel
mitochondrial protein mitoNEET and produce short-term neuroprotection and functional …

Mitochondria are dynamic organelles responsible for cellular energy production. Besides,
regulating energy homeostasis, mitochondria are responsible for calcium homeostasis …