From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis

DL Leyton, AE Rossiter, IR Henderson - Nature Reviews Microbiology, 2012 - nature.com
Autotransporters are a superfamily of proteins that use the type V secretion pathway for their
delivery to the surface of Gram-negative bacteria. At first glance, autotransporters look to …

[HTML][HTML] Type V secretion: from biogenesis to biotechnology

P Van Ulsen, S ur Rahman, WSP Jong… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The two membranes of Gram-negative bacteria contain protein machines that have a
general function in their assembly. To interact with the extra-cellular milieu, Gram-negatives …

Type V secretion systems in bacteria

E Fan, N Chauhan, DG Udatha… - … of Bacterial Pathogens, 2016 - Wiley Online Library
Gram‐negative bacteria are surrounded by two membranes, called the outer and inner
membranes. The space between these membranes, the periplasm, is spanned by a …

The inverse autotransporter family: intimin, invasin and related proteins

JC Leo, P Oberhettinger, M Schütz, D Linke - International Journal of …, 2015 - Elsevier
Intimin and invasin are adhesins and central virulence factors of attaching and effacing
bacteria, such as enterohaemorrhagic Escherichia coli, and enteropathogenic Yersiniae …

Structures and functions of autotransporter proteins in microbial pathogens

I Benz, MA Schmidt - International Journal of Medical Microbiology, 2011 - Elsevier
Since their discovery more than 20 years ago the autotransporter protein superfamily has
been growing continuously and currently represents the largest protein family in …

Autotransporter-based cell surface display in Gram-negative bacteria

T Nicolay, J Vanderleyden… - Critical reviews in …, 2015 - Taylor & Francis
Cell surface display of proteins can be used for several biotechnological applications such
as the screening of protein libraries, whole cell biocatalysis and live vaccine development …

SadA, a trimeric autotransporter from Salmonella enterica serovar Typhimurium, can promote biofilm formation and provides limited protection against infection

D Raghunathan, TJ Wells, FC Morris… - Infection and …, 2011 - Am Soc Microbiol
Salmonella enterica is a major cause of morbidity worldwide and mortality in children and
immunocompromised individuals in sub-Saharan Africa. Outer membrane proteins of …

Size and conformation limits to secretion of disulfide-bonded loops in autotransporter proteins

DL Leyton, YR Sevastsyanovich, DF Browning… - Journal of Biological …, 2011 - ASBMB
Autotransporters are a superfamily of virulence factors typified by a channel-forming C
terminus that facilitates translocation of the functional N-terminal passenger domain across …

Folding control in the path of type 5 secretion

N Dautin - Toxins, 2021 - mdpi.com
The type 5 secretion system (T5SS) is one of the more widespread secretion systems in
Gram-negative bacteria. Proteins secreted by the T5SS are functionally diverse (toxins …

A mortise–tenon joint in the transmembrane domain modulates autotransporter assembly into bacterial outer membranes

DL Leyton, MD Johnson, R Thapa… - Nature …, 2014 - nature.com
Bacterial autotransporters comprise a 12-stranded membrane-embedded β-barrel domain,
which must be folded in a process that entraps segments of an N-terminal passenger …