While the neural crest cell population gives rise to an extraordinary array of derivatives,
including elements of the craniofacial skeleton, skin pigmentation, and peripheral nervous …

Introduction Clear cell sarcoma (CCS) is an ultrarare soft tissue sarcoma (STS) with a poor
prognosis due to its propensity to metastasize and its low chemosensitivity. The standard …

Cysteine-focused chemical proteomic platforms have accelerated the clinical development
of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic …

A subset of malignant testicular sex cord tumors (TSCTs), heretofore interpreted as Sertoli
cell tumors, not otherwise specified, exhibits distinctive morphologic features that partially …

Population-scale databases have expanded to millions of protein-coding variants, yet insight
into their mechanistic consequences has lagged. Here we present PROD-ATAC, a high …

Simple Summary CIC-DUX4-rearranged sarcoma (CDS) is a rare and aggressive soft tissue
tumor predominantly affecting young adults for which the only oncogenic driver is the CIC …

Survival for children with cancer has primarily improved over the past decades due to
refinements in surgery, radiation and chemotherapy. Although these general therapies are …

Simple Summary Many cancers, especially those most common in adolescents and young
adults, are initiated by a single change in the DNA sequence of a gene. The particular …

We describe exciting recent advances in fusion-driven sarcoma etiology, from an
epigenetics perspective. By exploring the current state of the field, we identify and describe …

Ewing sarcoma is a cancer of children and young adults characterized by the critical
translocation-associated fusion oncoprotein EWSR1:: FLI1. EWSR1:: FLI1 targets …