The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …

Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells
to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key …

Epithelial organoids recapitulate multiple aspects of real organs, making them promising
models of organ development, function and disease,,. However, the full potential of …

Epithelial regeneration is critical for barrier maintenance and organ function after intestinal
injury. The intestinal stem cell (ISC) niche provides Wnt, Notch and epidermal growth factor …

Several cell populations have been reported to possess intestinal stem cell (ISC) activity
during homeostasis and injury-induced regeneration. Here, we explored inter-relationships …

Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal
epithelium has become a prime model for studying adult stem cells in health and disease …

The cancer stem cell (CSC) hypothesis has captured the attention of many scientists. It is
believed that elimination of CSCs could possibly eradicate the whole cancer. CSC surface …

Differentiation of human pluripotent stem cells (hPSCs) into organ-specific subtypes offers
an exciting avenue for the study of embryonic development and disease processes, for …

Leucine-rich repeat-containing G-protein coupled receptor 5-positive (Lgr5+) stem cells
reside at crypt bottoms of the small and large intestine. Small intestinal Paneth cells supply …

The intestinal epithelium is a rapidly renewing cellular compartment. This constant
regeneration is a hallmark of intestinal homeostasis and requires a tightly regulated balance …