Enzymes of the UDP-glucuronosyltransferase (UGT) superfamily contribute to the
elimination of drugs from almost all therapeutic classes. Awareness of the importance of …

UDP-glycosyltransferases (UGTs), important enzymes in biotransformation, control the
levels and distribution of numerous endogenous signaling molecules and the metabolism of …

This study aimed to develop a solid dispersion formulation of silymarin (Silymarin-SD) using
freeze-drying method to enhance its oral bioavailability (BA) by inhibiting the intestinal first …

The purpose of this study was to investigate the herb–drug interactions involving red
ginseng extract (RGE) or ginsenoside Rc with valsartan, a substrate for organic anion …

GSK-650394 is an inhibitor of serum-and glucocorticoid-regulated kinase 1 that displays
potency for treating cancer, hypertension, cardiovascular and neuronal diseases, such as …

Like flavonoids, biflavonoids, dimeric flavonoids, and polyphenolic plant secondary
metabolites have antioxidant, antibacterial, antiviral, anti-inflammatory, and anti-cancer …

Ticagrelor is the first reversibly binding, direct-acting, oral P2Y12 receptor inhibitor. The
contribution of UDP-glucuronosyltransferases (UGTs) enzymes to the metabolism of …

Ginsenoside Rc, a dammarane-type tetracyclic triterpenoid saponin primarily derived from
Panax ginseng, has garnered significant attention due to its diverse pharmacological …

The clinical application of herbal medicines is increasing, but there is still a lack of
comprehensive safety data and in-depth research into mechanisms of action. The …

Methylophiopogonanone A (MOA) is an abundant homoisoflavonoid in the Chinese herb
Ophiopogonis Radix. Recent investigations revealed that MOA inhibited several human …