The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Protein subcellular localization is tightly controlled and intimately linked to protein function in
health and disease. Capturing the spatial proteome—that is, the localizations of proteins and …

Autophagosome biogenesis is a dynamic membrane event, which is executed by the
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …

Alzheimer's disease (AD) is a debilitating, chronic neurodegenerative disease. Genetic
studies involving genome-wide association studies (GWAS) and meta-analysis have …

The multispanning membrane protein ATG9A is a scramblase that flips phospholipids
between the two membrane leaflets, thus contributing to the expansion of the phagophore …

The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

Cells have developed elaborate quality-control mechanisms for proteins and organelles to
maintain cellular homeostasis. Such quality-control mechanisms are maintained by …

Artemisinin and its derivatives (ARTs) are the frontline drugs against malaria, but resistance
is jeopardizing their effectiveness. ART resistance is mediated by mutations in the parasite's …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …