Bacteria of the genus Legionella are natural pathogens of amoebae that can cause a severe
pneumonia in humans called Legionnaires' Disease. Human disease results from inhalation …

Protein kinases are present in all domains of life and play diverse roles in cellular signaling.
Whereas the impact of substrate phosphorylation by protein kinases has long been …

Interferons (IFNs) induce an antimicrobial state, protecting tissues from infection. Many
viruses inhibit IFN signaling, but whether bacterial pathogens evade IFN responses remains …

Through coevolution with host cells, microorganisms have acquired mechanisms to avoid
the detection by the host surveillance system and to use the cell's supplies to establish …

Xenophagy is an evolutionarily conserved host defensive mechanism to eliminate invading
microorganisms through autophagic machinery. The intracellular bacterial pathogen …

Abstract The Legionella pneumophila Sde family of translocated proteins promotes host
tubular endoplasmic reticulum (ER) rearrangements that are tightly linked to phosphoribosyl …

Abstract The caspase-4/11-GSDMD pyroptosis axis recognizes cytosolic lipopolysaccharide
for antibacterial defenses. Shigella flexneri employs an OspC3 effector to block pyroptosis …

Regulation through post‐translational ubiquitin signaling underlies a large portion of
eukaryotic biology. This has not gone unnoticed by invading pathogens, many of which have …

Legionella pneumophila promotes its survival and replication in phagocytes by actively
modulating cellular processes using effectors injected into host cells by its Dot/Icm type IV …

To prevail in the interaction with eukaryotic hosts, many bacterial pathogens use protein
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …