TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
Role of TET enzymes in DNA methylation, development, and cancer
KD Rasmussen, K Helin - Genes & development, 2016 - genesdev.cshlp.org
The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene
expression, and DNA methylation abnormalities are often observed in diseases. The ten …
expression, and DNA methylation abnormalities are often observed in diseases. The ten …
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells
Mutations in the epigenetic modifiers DNMT3A and TET2 non-randomly co-occur in
lymphoma and leukemia despite their epistasis in the methylation–hydroxymethylation …
lymphoma and leukemia despite their epistasis in the methylation–hydroxymethylation …
Vitamin C in stem cell reprogramming and cancer
Vitamin C is an essential dietary requirement for humans. In addition to its known role as an
antioxidant, vitamin C is a cofactor for Fe 2+-and α-ketoglutarate-dependent dioxygenases …
antioxidant, vitamin C is a cofactor for Fe 2+-and α-ketoglutarate-dependent dioxygenases …
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
Mutant IDH1 downregulates ATM and alters DNA repair and sensitivity to DNA damage independent of TET2
Mutations in the isocitrate dehydrogenase-1 gene (IDH1) are common drivers of acute
myeloid leukemia (AML) but their mechanism is not fully understood. It is thought that IDH1 …
myeloid leukemia (AML) but their mechanism is not fully understood. It is thought that IDH1 …
TET family dioxygenases and DNA demethylation in stem cells and cancers
The methylation of cytosine and subsequent oxidation constitutes a fundamental epigenetic
modification in mammalian genomes, and its abnormalities are intimately coupled to various …
modification in mammalian genomes, and its abnormalities are intimately coupled to various …
The DNA dioxygenase Tet1 regulates H3K27 modification and embryonic stem cell biology independent of its catalytic activity
Abstract Tet enzymes (Tet1/2/3) oxidize 5-methylcytosine to promote DNA demethylation
and partner with chromatin modifiers to regulate gene expression. Tet1 is highly expressed …
and partner with chromatin modifiers to regulate gene expression. Tet1 is highly expressed …
DNA demethylation pathways: additional players and regulators
M Bochtler, A Kolano, GL Xu - Bioessays, 2017 - Wiley Online Library
DNA demethylation can occur passively by “dilution” of methylation marks by DNA
replication, or actively and independently of DNA replication. Direct conversion of 5 …
replication, or actively and independently of DNA replication. Direct conversion of 5 …
Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies
DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon
silencing, genomic imprinting, X-chromosome inactivation, and cancer. Cancer cells display …
silencing, genomic imprinting, X-chromosome inactivation, and cancer. Cancer cells display …