Oxidative stress, a term that describes the imbalance between oxidants and antioxidants,
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …

Neuroinflammation plays a pivotal role in Alzheimer's disease (AD) and Parkinson's disease
(PD), the leading causes of dementia. These neurological disorders are characterized by the …

Abstract Alzheimer's disease (AD), an age-dependent neurodegenerative disorder, is the
main cause of dementia. Common hallmarks of AD include the amyloid β-peptide (Aβ) …

Abstract Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that
regulates the expression of genes involved in the metabolism, immune response, cellular …

Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

A failure in redox homeostasis is a common hallmark of Alzheimer's Disease (AD) and
Parkinson's Disease (PD), two age-dependent neurodegenerative disorders (NDD), causing …

The transcription factor nuclear factor erythroid-derived 2-like 2 (NRF2) participates in the
activation of the antioxidant cytoprotective pathway and other important physiological …

The transcription factor Nrf2 (NF-E2-related factor 2) plays a vital role in maintaining cellular
homeostasis, especially upon the exposure of cells to chemical or oxidative stress, through …

Endothelial dysfunction is an important risk factor for cardiovascular disease, and it
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …

An elaborate network of highly inducible proteins protects aerobic cells against the
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …