Chimeric antigen receptor (CAR) T cells have proven that engineered immune cells can
serve as a powerful new class of cancer therapeutics. Clinical experience has helped to …

Human immunoglobulin preparations for intravenous or subcutaneous administration are
the cornerstone of treatment in patients with primary immunodeficiency diseases affecting …

High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …

Adenoviruses (AdVs) are DNA viruses that typically cause mild infections involving the
upper or lower respiratory tract, gastrointestinal tract, or conjunctiva. Rare manifestations of …

Several small-molecule Bruton tyrosine kinase (BTK) inhibitors are in development for B cell
malignancies and autoimmune disorders, each characterized by distinct potency and …

Neonates have an immature immune system, which cannot adequately protect against
infectious diseases. Early in life, immune protection is accomplished by maternal antibodies …

Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …

Health disparities are health differences linked with economic, social, and environmental
disadvantage. They adversely affect groups that have systematically experienced greater …

Bruton's tyrosine kinase (BTK) was initially discovered as a critical mediator of B cell
receptor signaling in the development and functioning of adaptive immunity. Growing …

Natural antibodies (NAb) are defined as germline encoded immunoglobulins found in
individuals without (known) prior antigenic experience. NAb bind exogenous (eg, bacterial) …