Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease
The amyloid hypothesis has driven drug development strategies for Alzheimer's disease for
over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally …
over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally …
Effects of neurotrophic factors in glial cells in the central nervous system: expression and properties in neurodegeneration and injury
S Pöyhönen, S Er, A Domanskyi… - Frontiers in physiology, 2019 - frontiersin.org
Astrocytes, oligodendrocytes, and microglia are abundant cell types found in the central
nervous system and have been shown to play crucial roles in regulating both normal and …
nervous system and have been shown to play crucial roles in regulating both normal and …
GDNF, NGF and BDNF as therapeutic options for neurodegeneration
SJ Allen, JJ Watson, DK Shoemark, NU Barua… - Pharmacology & …, 2013 - Elsevier
Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor
(NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival …
(NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival …
Amyloid precursor protein processing and Alzheimer's disease
RJ O'brien, PC Wong - Annual review of neuroscience, 2011 - annualreviews.org
Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …
Neurodegenerative tauopathies
▪ Abstract The defining neuropathological characteristics of Alzheimer's disease are
abundant filamentous tau lesions and deposits of fibrillar amyloid β peptides. Prominent …
abundant filamentous tau lesions and deposits of fibrillar amyloid β peptides. Prominent …
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
C Ballatore, VMY Lee, JQ Trojanowski - Nature reviews neuroscience, 2007 - nature.com
Advances in our understanding of the mechanisms of tau-mediated neurodegeneration in
Alzheimer's disease (AD) and related tauopathies, which are characterized by prominent …
Alzheimer's disease (AD) and related tauopathies, which are characterized by prominent …
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
M Baker, IR Mackenzie, SM Pickering-Brown, J Gass… - Nature, 2006 - nature.com
Frontotemporal dementia (FTD) is the second most common cause of dementia in people
under the age of 65 years. A large proportion of FTD patients (35–50%) have a family history …
under the age of 65 years. A large proportion of FTD patients (35–50%) have a family history …
Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission
S Marinelli, B Basilico, MC Marrone… - Seminars in cell & …, 2019 - Elsevier
The continuous crosstalk between microglia and neurons is required for microglia
housekeeping functions and contributes to brain homeostasis. Through these exchanges …
housekeeping functions and contributes to brain homeostasis. Through these exchanges …
Multi-target-directed ligands to combat neurodegenerative diseases
Our understanding of the pathogenesis of diseases has advanced enormously in recent
decades. As a consequence, drug discovery has gradually shifted from an entirely …
decades. As a consequence, drug discovery has gradually shifted from an entirely …
Factors that influence adult neurogenesis as potential therapy
Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside
within distinct regions of the brain. This phenomenon was first described over 50 years ago …
within distinct regions of the brain. This phenomenon was first described over 50 years ago …