Pathogenesis of alcohol-associated liver disease
Excessive alcohol consumption is a global healthcare problem with enormous social,
economic, and clinical consequences. While chronic, heavy alcohol consumption causes …
economic, and clinical consequences. While chronic, heavy alcohol consumption causes …
Metabolomic and lipidomic biomarkers for premalignant liver disease diagnosis and therapy
In recent years, there has been a plethora of attempts to discover biomarkers that are more
reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma …
reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma …
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease
Chronic liver disease due to alcohol-use disorder contributes markedly to the global burden
of disease and mortality,–. Alcoholic hepatitis is a severe and life-threatening form of alcohol …
of disease and mortality,–. Alcoholic hepatitis is a severe and life-threatening form of alcohol …
Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans
L Maccioni, B Gao, S Leclercq, B Pirlot, Y Horsmans… - Gut …, 2020 - Taylor & Francis
Background Animal data suggest a role of the gut-liver axis in progression of alcoholic liver
disease (ALD), but human data are scarce especially for early disease stages. Methods We …
disease (ALD), but human data are scarce especially for early disease stages. Methods We …
Intestinal virome in patients with alcoholic hepatitis
Background and Aims Alcoholic hepatitis (AH) is a severe manifestation of alcohol‐
associated liver disease (ALD) with high mortality. Although gut bacteria and fungi modulate …
associated liver disease (ALD) with high mortality. Although gut bacteria and fungi modulate …
Changes in the fecal bacterial microbiota associated with disease severity in alcoholic hepatitis patients
ABSTRACT Background and Aims Alcoholic hepatitis is the most severe form of alcohol-
related liver disease. While the gut microbiome is known to play a role in disease …
related liver disease. While the gut microbiome is known to play a role in disease …
[PDF][PDF] Transcriptional dynamics of hepatic sinusoid‐associated cells after liver injury
MK Terkelsen, SM Bendixen, D Hansen… - …, 2020 - Wiley Online Library
Background and Aims Hepatic sinusoidal cells are known actors in the fibrogenic response
to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and …
to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and …
Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice
RN Helsley, T Miyata, A Kadam, V Varadharajan… - Elife, 2022 - elifesciences.org
There is mounting evidence that microbes residing in the human intestine contribute to
diverse alcohol-associated liver diseases (ALD) including the most deadly form known as …
diverse alcohol-associated liver diseases (ALD) including the most deadly form known as …
The role of platelets in non-alcoholic fatty liver disease: from pathophysiology to therapeutics
Platelets are one of the key mediators in thrombosis as well as in the progression of many
diseases. An increase in platelet activation and a decrease in platelet count is associated …
diseases. An increase in platelet activation and a decrease in platelet count is associated …
Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development
Liver cancer is a malignancy developed from underlying liver disease that encompasses
liver injury and metabolic disorders. The progression from these underlying liver disease to …
liver injury and metabolic disorders. The progression from these underlying liver disease to …