Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

The integrin family of cell adhesion receptors regulates a diverse array of cellular functions
crucial to the initiation, progression and metastasis of solid tumours. The importance of …

Integrins are transmembrane receptors that have been implicated in the biology of various
human physiological and pathological processes. These molecules facilitate cell …

Aberrant expression of vascular cell adhesion molecule-1 (VCAM-1) in breast cancer cells is
associated with lung relapse, but the role of VCAM-1 as a mediator of metastasis has …

During angiogenesis, αv integrins are overexpressed on the endothelial cell surface to
facilitate the growth and survival of newly forming vessels. Accordingly, blocking αv integrin …

Src is a non‐receptor cytoplasmic tyrosine kinase which becomes activated following the
stimulation of plasma membrane receptors including receptor tyrosine kinases and integrins …

Integrins are a large family of adhesion molecules that mediate cell-cell and cell-
extracellular matrix interactions. Among the 24 integrin isoforms, many have been found to …

Integrins regulate adhesion-dependent growth, survival and invasion of tumor cells. In
particular, expression of integrin αvβ3 is associated with progression of a variety of human …

Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR).
AREG plays a central role in mammary gland development and branching morphogenesis …

The role of the fibronectin receptor, α 5 β 1-integrin, as an adhesion receptor and in
angiogenesis is well established. However, its role in cancer cell invasion and metastasis is …