The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease

M Wu, S Wu, W Chen, YP Li - Cell Research, 2024 - nature.com
Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …

[HTML][HTML] TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease

M Wu, G Chen, YP Li - Bone research, 2016 - nature.com
Transforming growth factor-beta (TGF-β) and bone morphogenic protein (BMP) signaling
has fundamental roles in both embryonic skeletal development and postnatal bone …

BMP signalling in skeletal development, disease and repair

VS Salazar, LW Gamer, V Rosen - Nature Reviews Endocrinology, 2016 - nature.com
Since the identification in 1988 of bone morphogenetic protein 2 (BMP2) as a potent inducer
of bone and cartilage formation, BMP superfamily signalling has become one of the most …

[HTML][HTML] Bone Morphogenetic Protein (BMP) signaling in development and human diseases

RN Wang, J Green, Z Wang, Y Deng, M Qiao… - Genes & diseases, 2014 - Elsevier
Abstract Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that
belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially …

Bone morphogenetic protein receptor signal transduction in human disease

MC Gomez‐Puerto, PV Iyengar… - The journal of …, 2019 - Wiley Online Library
Bone morphogenetic proteins (BMPs) are secreted cytokines that were initially discovered
on the basis of their ability to induce bone. Several decades of research have now …

Developmental regulation of the growth plate

HM Kronenberg - Nature, 2003 - nature.com
Vertebrates do not look like jellyfish because the bones of their skeletons are levers that
allow movement and protect vital organs. Bones come in an enormous variety of shapes and …

TGF-β family signaling in mesenchymal differentiation

I Grafe, S Alexander, JR Peterson… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

Bone morphogenetic proteins

DI Chen, M Zhao, GR Mundy - Growth factors, 2004 - Taylor & Francis
Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …

Bone morphogenetic protein receptors and signal transduction

K Miyazono, Y Kamiya, M Morikawa - Journal of biochemistry, 2010 - academic.oup.com
Bone morphogenetic proteins (BMPs) exhibit broad spectra of biological activities in various
tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung …

The BMP pathway and its inhibitors in the skeleton

JW Lowery, V Rosen - Physiological reviews, 2018 - journals.physiology.org
Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming
growth factor-β family of ligands. BMPs exhibit widespread utility and pleiotropic, context …