Objective: Recent outcomes enhanced the critical role of glycosylation pattern of
autoantibodies in the pathophysiology of antibody-mediated autoimmune diseases. In this …

The pathogenesis of autoantibody-mediated cellular and tissue lesions in autoimmune
diseases is most straightforwardly attributable to the combined action of self-antigen binding …

Replacement of aspartic acid by alanine at position 265 (D265A) in mouse IgG1 results in a
complete loss of interaction between this isotype and low-affinity IgG Fc receptors (FcγRIIB …

MRL/lpr mice develop a human lupuslike syndrome and, as in autoimmune
lymphoproliferative syndrome (ALPS), massive lymphoproliferation due to inactivation of Fas …

The most common renal injury associated with hepatitis C virus infection, in patients both
with and without evidence of cryoglobulinemia, is membranoproliferative glomerulonephritis …

Murine phagocytes express three different activating IgG FcγR: FcγRI is specific for IgG2a;
FcγRIII for IgG1, IgG2a, and IgG2b; and FcγRIV for IgG2a and IgG2b. Although the role of …

The kidney is frequently involved in the course of monoclonal gammopathies (MG). Renal
involvement presents different clinical-morphological patterns, which can occur either at the …

Abstract Monoclonal 6-19 IgG3 anti-IgG2a rheumatoid factor derived from lupus-prone MRL-
Fas lpr mice can induce GN and cryoglobulinemia, but the features that confer nephritogenic …

Q fever infection can lead to chronic Q fever, a potentially lethal disease occurring in 1–5%
of patients infected with Coxiella burnetii, characterized by the persistence of this …

Mouse IgG3 is highly protective against several life-threatening bacteria. This isotype is the
only one among mouse IgGs that forms non-covalent oligomers, has increased functional …