The transcription factor p53 is an important regulator of a multitude of cellular processes. In
the presence of genotoxic stress, p53 is activated to facilitate DNA repair, cell cycle arrest …

Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy
are the common cancer treatments. However, the development of adverse effects resulting …

Corroles are exceptionally promising platforms for the development of agents for
simultaneous cancer-targeting imaging and therapy. Depending on the element chelated by …

Ethnopharmacological relevance Origanum majorana L., is an aromatic and medicinal plant
distributed in different parts of Mediterranean countries. This species is widely used in …

Background The inhibitor of apoptosis (IAP) protein Survivin and its splice variants are
differentially expressed in breast cancer tissues. Our previous work showed Survivin is …

Background Triple-negative breast cancers represent an important clinical challenge, as
these cancers do not respond to conventional endocrine therapies or other available …

The p53 tumor suppressor plays a major role in controlling the initiation and development of
cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 …

Ovarian cancer is one of the most important malignancies, and the origin, detection, and
pathogenesis of epithelial ovarian cancer remain elusive. Although many cancer drugs have …

Background In this study we investigated the in vitro and in vivo anticancer effect of carnosol,
a naturally occurring polyphenol, in triple negative breast cancer. Results We found that …

Colorectal cancer (CRC) is the third most common type of cancer in terms of incidence and
mortality worldwide. Here we have investigated the anti-colon cancer potential of Origanum …