▪ Abstract The neurons of the cochlear ganglion transmit acoustic information between the
inner ear and the brain. These placodally derived neurons must produce a topographically …

In mammals, the initial bridge between the physical world of sound and perception of that
sound is established by neurons of the spiral ganglion. The cell bodies of these neurons …

GABA (γ-aminobutyric acid) is the main inhibitory transmitter in the adult brain, and it exerts
its fast hyperpolarizing effect through activation of anion (predominantly Cl−)-permeant …

DURING vertebrate development, neuronal survival depends on target-derived neurotrophic
factors1, 2. Brain-derived neurotrophic factor3 (BDNF), a member of the neurotrophin family …

Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory
neuron survival and establishment of neuronal projections to sensory epithelia in the …

Brain-derived neurotrophic factor (BDNF), a neurotrophin, enhances the survival and
differentiation of several classes of neurons in vitro. To determine fts esaential functions, we …

In acquired sensorineural hearing loss, such as that produced by noise or aging, there can
be massive loss of the synaptic connections between cochlear sensory cells and primary …

Abstract Neurotrophin-3-deficient (NT-3-deficient) mice were generated by gene targeting.
Mutant mice displayed severe movement defects of the limbs, and most died shortly after …

DURING development, neurotrophins help shape the nervous system by regulating
neuronal survival and differentiation. Neurotrophin-3 (refs 1–5) is the most abundant …

The Brn-3 subfamily of POU–domain transcription factor genes consists of three highly
homologous members—Brn-3a, Brn-3b, and Brn-3c—that are expressed in sensory neurons …